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(4) alterations in brain neurotransmitters have been implicated in the pathogenesis of hepatic encephalopathy (Lozeva-Thomas, 2004[43]), a serious neuropsychiatric complication of both acute and chronic liver disease

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Mechanistically, honey enhances chemotherapeutic efficacy through multiple pathways: inhibition of drug efflux pumps (135), ROS-mediated apoptosis induction (136), and suppression of autophagy via AMPK/mTOR axis modulation (121)